发明名称 |
SOLID-PHASE METHOD OF PRODUCING BIOACTIVE NANOCOMPOSITE |
摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to synthetic polymer chemistry. The nanocomposite contains a matrix in form of a cross-linked salt of hyaluronic acid which is modified with sulphur-containing compounds and nanoparticles of a noble metal as filler. A film of the cross-linked salt of hyaluronic acid which is modified with sulphur-containing compounds is obtained through chemical reaction of the salt of hyaluronic acid with a mixture of two sulphur-containing compounds and with a cross-linking agent, under conditions with pressure between 50 and 300 MPa and shear deformation in a mechanical reactor at temperature between 20 and 30C. The reactor used to obtain the film is a Bridgman anvil. ^ EFFECT: invention enables to obtain a range of new bioactive nanocomposites with quantitative output and in the absence of a liquid medium, where the method does not require high energy, labour and water consumption and significantly increases efficiency of the composite; in particular, resistance to decomposition in the presence of hydroxyl radicals is 2-3 times higher compared to the control result. ^ 16 cl, 7 ex |
申请公布号 |
RU2416389(C1) |
申请公布日期 |
2011.04.20 |
申请号 |
RU20090139194 |
申请日期 |
2009.10.26 |
申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII NAUK INSTITUT SINTETICHESKIKH POLIMERNYKH MATERIALOV IM. N.S. ENIKOLOPOVA RAN (ISPM RAN);OOO "LABORATORIJA TOSKANI" |
发明人 |
VOLKOV VLADIMIR PETROVICH;ZELENETSKIJ ALEKSANDR NIKOLAEVICH;KHABAROV VLADIMIR NIKOLAEVICH;SELJANIN MIKHAIL ANATOL'EVICH;OBOLONKOVA ELENA SERGEEVNA |
分类号 |
A61K8/00;B82B3/00;C08B37/08;C08L5/08 |
主分类号 |
A61K8/00 |
代理机构 |
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