| 发明名称 |
Reducing the immunogenicity of fusion proteins |
| 摘要 |
<p>The present invention relates generally to methods and compositions for making and using modified fusion proteins with reduced or no immunogenicity as therapeutic agents. More specifically, the invention relates to fusion proteins, made less immunogenic by identifying candidate T-cell epitopes and modifying the amino acid sequence to eliminate such epitopes.</p> |
| 申请公布号 |
EP2311882(A1) |
申请公布日期 |
2011.04.20 |
| 申请号 |
EP20100010015 |
申请日期 |
2002.03.30 |
| 申请人 |
MERCK PATENT GMBH |
发明人 |
GILLIES, STEPHEN, D., DR. |
| 分类号 |
C07K16/46;C12N15/09;A61K38/00;A61K38/22;A61K38/24;A61K38/27;A61K45/00;A61K47/00;C07K1/00;C07K14/00;C07K14/505;C07K14/52;C07K14/54;C07K14/55;C07K14/575;C07K14/705;C07K14/725;C07K14/76;C07K16/00;C07K16/18;C07K17/00;C07K19/00;C12N15/62;G01N33/53 |
主分类号 |
C07K16/46 |
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