| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: described is a composition with inhibitory activity on BACE1, which contains a compound of general formula (I), where ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E denotes a lower alkylene; X is S, O or NR1; R1 denotes a hydrogen atom or lower alkyl; each R2a, R2b, R3a, R3b, R4a and R4b independently denotes a hydrogen atom, an optionally substituted alkyl or optionally substituted carbocyclic group; each n and m independently denotes an integer from 0 and 3; n+m equals an integer from 1 to 3; R5 denotes a hydrogen atom or an optionally substituted lower alkyl; a pharmaceutically acceptable salt or solvate thereof. Described also is a compound of formula (I) and a pharmaceutical composition. ^ EFFECT: highly effective treatment. ^ 21 cl, 170 tbl, 4 ex |
