发明名称 |
Microfluidic protein crystallography |
摘要 |
The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
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申请公布号 |
US7927422(B2) |
申请公布日期 |
2011.04.19 |
申请号 |
US20080326741 |
申请日期 |
2008.12.02 |
申请人 |
NATIONAL INSTITUTES OF HEALTH (NIH);THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT. OF HEALTH AND HUMAN SERVICES (DHHS);U.S. GOVERNMENT NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR) |
发明人 |
HANSEN CARL L.;SOMMER MORTEN;QUAKE STEPHEN R. |
分类号 |
C30B7/00;C30B1/00;C30B35/00 |
主分类号 |
C30B7/00 |
代理机构 |
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