发明名称 |
Inhibitors of PGHS-2Transactivator activity |
摘要 |
Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H2. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-&kgr;B regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity.
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申请公布号 |
US7927799(B2) |
申请公布日期 |
2011.04.19 |
申请号 |
US20060920910 |
申请日期 |
2006.05.23 |
申请人 |
ORDWAY RESEARCH INSTITUTE |
发明人 |
CAO HUIYU;LIN HUNG-YUN;DAVIS PAUL J.;DAVIS FAITH B. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
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