发明名称 PROCESS FOR THE PREPARATION OF DIOXANE ACETIC ACID ESTERS
摘要 Process for the preparation of an ester of formula (1), wherein R1represents a leaving group, CN, OH or a COOR5 group, R3 and R4each independently represent a 1-3 C alkyl group, and R2 and R5 each independently represent an ester residue, wherein the corresponding salt with formula (2), wherein M represents H or an alkali (earth) metal in an inert solvent is contacted with an acid chloride forming agent to form the corresponding acid chloride, and the acid chloride is contacted with an alcohol with formula R2OH in the presence of N-methyl-morpholine. Preferably M represents an alkali metal, and R2 represents an alkyl group, particularly a t.-butyl group. (1), (2)
申请公布号 CA2490205(C) 申请公布日期 2011.04.19
申请号 CA20032490205 申请日期 2003.06.12
申请人 ASTRAZENECA UK LIMITED 发明人 BAKEL VAN, HERMANUS CAROLUS CATHERINA KAREL;CALLANT, DOMINIQUE MONIQUE CHARLES;KOOISTRA, JACOB HERMANUS MATTHEUS HERO;MAAS, PETER JOHANNES DOMINICUS
分类号 C07D319/06;C07B53/00;C07B61/00 主分类号 C07D319/06
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