NOVEL SULFONAMIDE COMPOUNDS AS SEROTONIN RECEPTOR ANTAGONISTS AND SEROTONIN REUPTAKE INHIBITOR

摘要

PURPOSE: A sulfonamide compound and pharmaceutically acceptable salt thereof are provided to be used as an agent for preventing and treating central nervous system(CNS)-related diseases. CONSTITUTION: A sulfonamide derivative is denoted by chemical formula 1. A pharmaceutical composition contains the sulfonamide derivative and pharmaceutically acceptable salt thereof as an active ingredient. The composition is used for treating depression, obesity, psychosis, suicidal tendency, anxiety, appetite disorders, or sleep disorders. A method for preparing the sulfonamide compounds comprises: a step of performing reductive amination of a carbonyl compound of chemical formula 2 with primary amine compound of chemical formula 3 to prepare a secondary amine compound of chemical formula 4; and a step of performing sulfonization of the secondary amine compound of chemical formula 4 with a sulfonyl halide compound of chemical formula 5 to prepare a sulfonamide compound of chemical formula 1.