发明名称 |
COMPOSITE FOR DELIVERING A GENE INTO A CELL, PREPARATION METHOD THEREOF, AND METHOD OF DELIVERING A GENE INTO A CELL USING SAME |
摘要 |
PURPOSE: An intracellular gene delivery intracellular gene delivery containing cationic polymers and magnetic nanoaprticels is provided to treat various diseases using a gene. CONSTITUTION: An intracellular gene delivery composite contains cationic polymers of 1000-10,000 Da of molecular weight and magnetic nanoparticles. The cationic polymers are polyethylene imine(PEI), poly-L-lysine(PLL), or chitosan. The magnetic nanoparticles are thermally cross-linked superparamagnetic nanoparticles(TCL-SPION). The intracellular gene delivery composite is prepared by cross-linking of the cationic polymers and magnetic nanoparticles under the presence of -ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride(EDC) and N-hydroxysuccineimide(NHS). |
申请公布号 |
KR20110039046(A) |
申请公布日期 |
2011.04.15 |
申请号 |
KR20090096314 |
申请日期 |
2009.10.09 |
申请人 |
POSTECH ACADEMY-INDUSTRY FOUNDATION;INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY |
发明人 |
KIM, WON JONG;AHN, YOUNG KEUN;KIM, YONG SOOK;NAMGUNG, RAN;PARK, IN KYU |
分类号 |
C12N15/87;C08K7/18;C08L79/08 |
主分类号 |
C12N15/87 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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