| 摘要 |
SYNTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION 5 THE INVENTION RELATED TO A NOVEL PROCESS, NOVEL PROCESS STEPS AND NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS OF PHARMACEUTICALLY ACTIVE COMPOUNDS, ESPECIALLY RENIN INHIBITORS, SUCH AS ALISKIREN. INTER ALIA, THE INVENTION RELATES TO A PROCESS FOR THE MANUFACTURE OF A COMPOUND OF THE FORMULA (111), WHEREIN R, RI, AND 10 R' ARE AS DEFINED IN THE SPECIFICATION, OR A SALT THEREOF, AND A COMPOUND OF FORMULA (IV) WHEREIN R, RI, R7 AND R' ARE AS DEFINED IN THE SPECIFICATION, AND PROCESSES OF MANUFACTURING THESE.
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