发明名称 |
PROCESS FOR THE MANUFACTURE OF ENANTIOMERICALLY PURE ANTIFUNGAL AZOLES AS RAVUCONAZOLE AND ISAVUCONAZOLE |
摘要 |
Methods for the preparation of enantiomerically pure azole compounds of formula I are disclosed. In particular resolution of a racemic mixture of a compound of formula I is performed by addition of a chiral acid, collection of the desired diastereomer followed by conversion of the salt into an enantiomerically pure form of the compound of formula I by treatment with a base or ion-exchange resin. Also disclosed is a method of resolving a racemic precursor of formula I followed by reaction of the enantiomerically pure precursor to form a compound of formula I.
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申请公布号 |
WO2011042827(A1) |
申请公布日期 |
2011.04.14 |
申请号 |
WO2010IB54325 |
申请日期 |
2010.09.25 |
申请人 |
CARBODESIGN LLC;SOUKUP, MILAN |
发明人 |
SOUKUP, MILAN |
分类号 |
C07D417/06;C07D249/08 |
主分类号 |
C07D417/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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