发明名称 |
Transition state sturcture of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
摘要 |
Provided are methods of designing a putative inhibitor of a 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase. The methods comprise designing a chemically stable compound that resembles the charge and geometry of the 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase transition state. Also provided are methods of inhibiting 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidases using the inhibitors found by the above methods.
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申请公布号 |
US2011086812(A1) |
申请公布日期 |
2011.04.14 |
申请号 |
US20060988651 |
申请日期 |
2006.07.26 |
申请人 |
SCHRAMM VERN L |
发明人 |
SCHRAMM VERN L. |
分类号 |
A61K31/7076;A61P31/04;C07H19/16 |
主分类号 |
A61K31/7076 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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