发明名称 |
Fusion-Intermediate State of HIV-1 gP41 Targeted by Broadly Neutralizing Antibodies |
摘要 |
Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided.
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申请公布号 |
US2011086041(A1) |
申请公布日期 |
2011.04.14 |
申请号 |
US20100869967 |
申请日期 |
2010.08.27 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
CHEN BING;FREY GARY H.;HARRISON STEPHEN C. |
分类号 |
A61K39/42;A61K39/00;A61P31/18;C07K14/16;C07K16/00;C12N15/63;C40B30/04;G01N33/53 |
主分类号 |
A61K39/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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