发明名称 |
Process for modifying drug crystal formation |
摘要 |
Process for modifying the crystal habit of an acicular drug crystal wherein the acicular drug substance is a mycophenolate sodium salt, comprising suspending said crystalline drug substance in a methanol/water solvent and subjecting said suspension to a temperature oscillation, wherein the crystal habit is modified in that the mean aspect ratio of the processed crystals is smaller than 10:1 and the bulk density is above 200 kg/m 3 .
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申请公布号 |
EP2308471(A1) |
申请公布日期 |
2011.04.13 |
申请号 |
EP20100177718 |
申请日期 |
2004.01.19 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH |
发明人 |
PFEFFER, SABINE;WIECKHUSEN, DIRK |
分类号 |
A61K9/14;A61K9/28;C07D307/88 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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