| 摘要 |
<p>A process for the production of a sucrose-6-ester comprises:a) providing a first reaction mixture comprising sucrose, a solvent, and an organotin-based acylation promoter;b) removing water from the first reaction mixture to afford a second reaction mixture that is substantially free from water; andc) adding a carboxylic acid anhydride to the second reaction mixture to afford a third reaction mixture, thereby producing a sucrose-6-ester;in which: during step (b), the removal of water includes distillation of water with the reaction vehicle using an apparatus supplying a heat flux of from 1577 to 78865 W/m2 selected from a wiped film evaporator, an agitated thin film evaporator, a falling film evaporator, a rising film evaporator and the like.The sucrose-6-ester may be sucrose-6-acetate or sucrose-6-benzoate and may be subsequently converted to sucralose (1',4,6'- trichlorogalactosucrose, TGS). The solvent may be N,N-dimethyl formamide. The organotin reagent may be 1,3-diacetoxy-1,1,3,3-tetrabutyldistannoxane (DSDA, distannoxane diacetate).</p> |
