发明名称 |
Therapeutic and diagnostic applications based on the role of the CXCR-4 and SDF-1 genes in tumourigenesis |
摘要 |
<p>The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXC R- 4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.</p> |
申请公布号 |
EP2308996(A1) |
申请公布日期 |
2011.04.13 |
申请号 |
EP20100184637 |
申请日期 |
1999.03.29 |
申请人 |
NORTHWEST BIOTHERAPEUTICS, INC. |
发明人 |
MURPHY, GERALD P.;BOYNTON, ALTON L.;SEHGAL, ANIL |
分类号 |
C12Q1/68;G01N33/53;A61K31/711;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;C07H21/04;C07K14/715;C07K16/00;C07K16/24;C07K16/28;C07K16/32;C12N15/09;C12N15/11;C12N15/85 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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