发明名称 PROCESSES FOR PREPARING TRIETHANOLAMINE SALTS OF LOW MOLECULAR WEIGHT HEPARIN AND THEIR USE IN TOPICAL CREAMS FOR ANTITHROMBOTIC THERAPY
摘要 Low molecular weight heparin salt with triethanolamine useful as a therapeutic-antithrombotic agent for local delivery, having at least 60% of its total mass a molecular weight of less than 8000 Da and an average molecular weight from 4000 to 6000 Da, said salt also having a content of organic sulfur from 6.1 to 7,5 weight % (theoretical 6.8%) and a triethanolamine content from 42,6 to 52,1 weight % (theoretical 47,4 weight %). The processes for preparing the heparin salt, eliminating hygroscopicity of said salt, and pharmaceutical compositions for use in local antithrombotic therapy and its uses are also disclosed.
申请公布号 CA2491398(C) 申请公布日期 2011.04.12
申请号 CA20052491398 申请日期 2005.01.04
申请人 SYNTEX S.A. 发明人 DIAZ, VICTOR BAUTISTA;MARTINEZ, OSCAR EDUARDO
分类号 A61K9/06;A61K31/727;A61K9/107;A61K31/133;A61P7/02;A61P9/14;C08B37/00;C08B37/10 主分类号 A61K9/06
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