发明名称 |
Photocleavable linker methods and compositions |
摘要 |
Bifunctional linkers are provided that comprise a photocleavable moiety flanked by two different amine reactive moieties. In some embodiments the photocleavable moiety is a dimethoxynitrobenzyl moiety. In other embodiments the photocleavable moiety is 8-bromo-7-hydroxyquinoline. In other embodiments the photocleavable moiety is nitrodibenzofuran. In other embodiments the photocleavable moiety is 6-bromo-7-hydroxycoumarin-4-ylmethyl. The linkers find use in synthetic methods, including the generation of photocleavable oligonucleotides, e.g. caged morpholinos.
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申请公布号 |
US7923562(B2) |
申请公布日期 |
2011.04.12 |
申请号 |
US20090485774 |
申请日期 |
2009.06.16 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
CHEN JAMES K.;SINHA SURAJIT;SHESTOPALOV ILYA;OUYANG XIAOHU |
分类号 |
C07D311/16;C07C205/06;C07C229/22;C07D207/273;C07D207/46;C07D215/14;C07D307/91;C07D405/12 |
主分类号 |
C07D311/16 |
代理机构 |
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主权项 |
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地址 |
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