ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS
摘要
This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula (I). The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting .beta.-amyloid peptide release and/or synthesis, a method for inhibiting .gamma.--secretase activity, and a method for treating neurological disorders associated with .beta.-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula (I). The compounds of Formula (I) are useful in the prevention and treatment of Alzheimer's disease. (see formula I)
申请公布号
CA2528496(C)
申请公布日期
2011.04.12
申请号
CA20042528496
申请日期
2004.06.04
申请人
ELAN PHARMACEUTICALS, INC.
发明人
TUNG, JAY S.;GAROFALO, ALBERT;PLEISS, MICHAEL A.;DRESSEN, DARREN;GUINN, ASHLEY C.;JENKINS, SCOTT A.;LATIMER, LEE H.;SEALY, JENNIFER;TUCKER, JOHN;WONE, DAVID W. G.;WU, JING