发明名称 |
Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine |
摘要 |
The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).
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申请公布号 |
US7923459(B2) |
申请公布日期 |
2011.04.12 |
申请号 |
US20070733512 |
申请日期 |
2007.04.10 |
申请人 |
NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE |
发明人 |
GAUTHIER DONALD R.;DESMOND RICHARD;DEVINE PAUL N. |
分类号 |
A61K31/445 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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