发明名称 |
SYNTHESIS OF HIGH MOLECULAR WEIGHT IRON-SACCHARIDIC COMPLEXES |
摘要 |
A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe (III) and (OH)- ions and (ii) at least one saccharide, to form a reaction mixture, where the molar ratio of (i): (ii) is about 30:1 to about 1:30; and the mixture temperature and pH are at or above the complex assembly point (CAP); and (2) maintaining temperature and pH at or above the CAP for a time sufficient to form an iron-saccharidic complex having a molecular weight of about 25,000 Daltons or more. Control of the temperature and pH efficiently produces a high molecular weight complex. The complex can be separated by precipitation, dialysis and/or column fractionation and, if desired, dried, e.g., lyophilized or spray dried. The process can controllably synthesize complexes of varying molecular weight and/or chemical composition, particularly sodium ferric gluconate and ferric hydroxide-sucrose.
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申请公布号 |
CA2526771(C) |
申请公布日期 |
2011.04.12 |
申请号 |
CA20042526771 |
申请日期 |
2004.05.28 |
申请人 |
CHROMACEUTICAL ADVANCED TECHNOLOGIES, INC. |
发明人 |
BECK, ROBERT A.;MATEER, ROBERT A., JR.;KOWALSKI, JOHN |
分类号 |
A61K33/26;A61K;A61K31/191;A61K31/295;A61K31/70;A61K31/7004;A61K31/7008;A61K31/7012;A61K31/7016;A61K31/7024;A61K31/715;A61K45/06;A61K47/26;A61K47/30;A61K47/48;A61P3/02;A61P7/06;C07H3/00;C07H23/00;C08B37/02;C08G83/00 |
主分类号 |
A61K33/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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