发明名称 |
MULTILAYER DOSAGE FORMS WHICH CONTAIN ACTIVE SUBSTANCES AND WHICH COMPRISE A NEUTRAL CORE AND AN INNER AND OUTER COATING COMPOSED OF METHACRYLATE COPOLYMERS AND METHACRYLATE MONOMERS |
摘要 |
The invention relates to a multilayer dosage form comprised of: a) a neutral core; b) an inner coating consisting of a methacrylate copolymer; c) an outer coating consisting of a copolymer of which 40 to 95 % by weight is composed of radically polymerized C1 to C4 alkyl esters of acrylic acid or of methacrylic acid and of which 5 to 60 % by weight is composed of (meth)acrylate monomers having an anionic group in the alkyl radical. The invention is characterized in that the inner coating is essentially comprised of a methacrylate copolymer, of which at least up to 90 % by weight consists of (meth)acrylate monomers with neutral radicals, which, in accordance with DIN 53 787, has a minimum film formation temperature of no higher than 30 ~C, and which contains the pharmaceutical active substance in bound form.
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申请公布号 |
CA2502371(C) |
申请公布日期 |
2011.04.12 |
申请号 |
CA20032502371 |
申请日期 |
2003.09.04 |
申请人 |
ROEHM GMBH & CO. KG |
发明人 |
PETEREIT, HANS-ULRICH;RUDOLPH, MARKUS;DRESSMAN, JENNIFER;BECKERT, THOMAS |
分类号 |
A61K9/50;A61K9/16;A61K9/20;A61K9/28;A61K31/573;A61K31/58 |
主分类号 |
A61K9/50 |
代理机构 |
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主权项 |
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地址 |
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