NEW PROCESS FOR THE PRODUCTION OF A STABLE PHARMACEUTICAL COMPOSITION OF INTESTINE-SOLUBLE ACETYLSALICYLIC ACID TABLETS COATED WITH GASTRO-RESISTANT FILM

摘要

The invention relates to intestine-soluble acetylsalicylic acid tablets being coated with gastro-resistant film and remaining stable against the breakdown of the acetylsalicylic acid thanks to the production method of said tablets. More precisely, the invention relates to coated acetylsalicylic acid tablets where the decomposition of the acetylsalicylic acid (in acetyl acid and salicylic acid) is retarded by incorporation to tablets -before their final coating- of a quantity of polymeric coating material of pH lower than 3 (in the absence of other factors apart from polymer and plastifiers); the modification of the commonly accepted coating process using 5-5, 5 pH range involves improvement of the stability of the coated tablets and reduction of the production time thereof.