PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE
摘要
Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plkl. Further provided herein are methods for use of the compounds for the treatment of hyperprolif erative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament.
申请公布号
WO2010132869(A3)
申请公布日期
2011.04.07
申请号
WO2010US35069
申请日期
2010.05.17
申请人
GOVERNMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;BURKE, TERRENCE, R.;LIU, FA;LEE, KYUNG, S.;PARK, JUNG-EUN