发明名称 |
ACTIVATING MUTATIONS OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGFRA) AS DIAGNOSTIC MARKERS AND THERAPEUTIC TARGET |
摘要 |
This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.
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申请公布号 |
US2011081730(A1) |
申请公布日期 |
2011.04.07 |
申请号 |
US20100959588 |
申请日期 |
2010.12.03 |
申请人 |
OREGON HEALTH & SCIENCE UNIVERSITY;GOVERNMENT OF THE UNITED STATES, D.B.A. THE DEPARTMENT OF VETERANS AFFAIRS;DANA-FARBER CANCER INSTITUTE;BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
HEINRICH MICHAEL C.;CORLESS CHRISTOPHER C.;FLETCHER JONATHAN A.;DEMETRI GEORGE D. |
分类号 |
G01N33/53;A61K38/00;C07K7/06;C07K7/08;C07K14/71;C12N15/12;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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