发明名称 |
CONDENSED RING PYRIDINE COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-2 (S1P2) RECEPTORS |
摘要 |
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these compounds selected from the group consisting of wherein A, B, C, D, X, Y, Z and R3 are defined in the specification. Said compounds are useful for treating a disease or condition of a mammal selected from the group consisting of ocular diseases; systemic vascular barrier related diseases; allergies and other inflammatory diseases; cardiac diseases or conditions; fibrosis; pain and wounds.
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申请公布号 |
CA2775587(A1) |
申请公布日期 |
2011.04.07 |
申请号 |
CA20102775587 |
申请日期 |
2010.09.28 |
申请人 |
ALLERGAN, INC. |
发明人 |
FANG, WENKUI KEN;WANG, LIMING;CORPUZ, EVELYN G.;CHOW, KEN;IM, WHA-BIN |
分类号 |
C07D215/38;A61K31/136;A61K31/661;C07D471/04 |
主分类号 |
C07D215/38 |
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