| 摘要 |
The present invention provides a method for efficiently producing a &bgr;-alanyl-amino acid (e.g., carnosine) or derivative thereof. Specifically, it provides a method for producing a &bgr;-alanyl-amino acid (e.g., &bgr;-alanyl-histidine) or derivative thereof, by reacting a &bgr;-alanyl ester or a &bgr;-alanyl amide and an amino acid or derivative thereof in the presence of an enzyme or an enzyme-containing product that has an ability to form the &bgr;-alanyl-amino acid (e.g., &bgr;-alanyl-histidine) or derivative thereof from the &bgr;-alanyl ester or the &bgr;-alanyl amide and the amino acid (e.g., histidine) or derivative thereof. The present invention also provides a protein which is able to catalyze production of a &bgr;-alanyl-amino acid or derivative thereof from a &bgr;-alanyl ester or a &bgr;-alanyl amide and an amino acid or derivative thereof, and a polynucleotide encoding said protein.
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