An inactivated influenza virus preparation is described which comprises a haemagglutinin antigen stabilised in the absence of thiomersal, or at low levels of thiomersal, wherein the haemagglutinin is detectable by a SRD assay. The influenza virus preparation may comprise a micelle modifying excipient, for example a- tocopherol or a derivative thereof in a sufficient amount to stabilise the haemagglutinin.
申请公布号
WO2011039180(A2)
申请公布日期
2011.04.07
申请号
WO2010EP64352
申请日期
2010.09.28
申请人
GLAXOSMITHKLINE BIOLOGICALS, NIEDERLASSUNG DER SMITHKLINE BEECHAM PHARMA GMBH & CO. KG;EICHHORN, UWE;SAENGER, ROLAND HERBERT