发明名称 |
(20S,22E)-2-METHYLENE-19-NOR-22-ENE-1a,25-DIHYDROXYVITAMIN D3 ANALOGS |
摘要 |
This invention discloses (20S.22E)-2-mcthylenc-19-nor-22-enc-1a,25- dihydroxyvitamin D3 analogs, and specifically(20S,22E)-2 -methylene- 19-nor-22-ene- 1 a,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits significant vitamin D receptor binding activity and transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent, especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. |
申请公布号 |
WO2011041579(A2) |
申请公布日期 |
2011.04.07 |
申请号 |
WO2010US50956 |
申请日期 |
2010.09.30 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;DELUCA, HECTOR, F.;GRZYWACZ, PAWEL;PLUM, LORI, A.;CLAGETT-DAME, MARGARET |
发明人 |
DELUCA, HECTOR, F.;GRZYWACZ, PAWEL;PLUM, LORI, A.;CLAGETT-DAME, MARGARET |
分类号 |
A61K31/593;A61P35/00;C07C35/21 |
主分类号 |
A61K31/593 |
代理机构 |
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