A heparanase activity inhibitor comprising a cyclic carboxamide derivative represented by general formula (I) (wherein n represents an integer of 1 to 3; R1 represents a hydrogen atom, or a hydrocarbon group which has 1 to 6 carbon atoms and may be substituted by a hydroxy group; X represents a group represented by the formula -CH2- or -N(R2)-; and R2 represents a hydrogen atom, or a hydrocarbon group which has 1 to 6 carbon atoms and may be substituted by a hydroxy group) or a salt thereof as an active ingredient.
