摘要 |
<p>The present invention relates to novel analogues of insulin-like growth factor- 1 (IGF- 1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1 -receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-I having an amino acid substitution at position 59, e.g., (Asn59)hIGF- 1(1 -7O)-OH (SEQ ID NO: 1), and other substitution(s) as defined herein.</p> |
申请人 |
IPSEN PHARMA S.A.S.;DONG, ZHENG, XIN;PRAIRIE, NICHOLAS, C.;UFRET, MARIA, L.;ZHANG, JUNDONG;ROTHMAN, DEBORAH;COMSTOCK, JEANNE, MARY |
发明人 |
DONG, ZHENG, XIN;PRAIRIE, NICHOLAS, C.;UFRET, MARIA, L.;ZHANG, JUNDONG;ROTHMAN, DEBORAH;COMSTOCK, JEANNE, MARY |