发明名称 |
COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS |
摘要 |
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is—CR4═CR5.
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申请公布号 |
US2011081365(A1) |
申请公布日期 |
2011.04.07 |
申请号 |
US20090921129 |
申请日期 |
2009.02.27 |
申请人 |
IRM LLC;NOVARTIS 35 |
发明人 |
CORTEZ ALEX;LI YONGKAI;MISHRA PRANAB;SINGH MANMOHAN;SKIBINSKI DAVID;VALIANTE NICHOLAS;WU TOM YAO-HSIANG;ZHANG XIAOYUE;ZOU YEFEN |
分类号 |
A61K39/00;A61K31/438;A61K31/4985;A61K31/519;A61K31/5377;A61P11/06;A61P37/02;A61P37/04;C07D239/70;C07D413/14;C07D471/04;C07D495/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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地址 |
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