发明名称 |
APOLIPOPROTEIN A-1 MIMIC PEPTIDES, AND THERAPEUTIC AGENT FOR TREATING HYPERLIPIDEMIA AND DISEASES RELATED TO HYPERLIPIDEMIA COMPRISING SAME |
摘要 |
<p>The present invention relates to apolipoprotein A-1 mimic peptides, and therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia comprising the same. More specifically, the apolipoprotein A-1 mimic peptides of the present invention were manufactured by modifying hydrophilic or hydrophobic face of existing 4F amphipathic peptides to produce Apo A-1 mimic peptides which specifically bind with cholesterol ester to allow high density lipoprotein content to increase, and the peptide of which phenylalanine in hydrophobic face of 4F is substituted with 2-naphtilalanine has superior cholesterol efflus capability and cognitive function for lipids to the existing 4F peptides, among the mimic peptides. Thus, the Apo A-1 mimic peptides of the present invention can be used as Apo A-1 mimic peptides and as a therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia.</p> |
申请公布号 |
WO2011040654(A1) |
申请公布日期 |
2011.04.07 |
申请号 |
WO2009KR05607 |
申请日期 |
2009.09.30 |
申请人 |
SNU R&DB FOUNDATION;YU, JAEHOON |
发明人 |
YU, JAEHOON |
分类号 |
C07K14/775;A61K38/17;A61P3/06;G01N33/68 |
主分类号 |
C07K14/775 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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