DIAGNOSIS KIT AND CHIP FOR BLADDER CANCER USING BLADDER CANCER SPECIFIC METHYLATION MARKER GENE

摘要

PURPOSE: A kit for diagnosing bladder cancer using a bladder cancer-specific marker gene is provided to quickly and accurately diagnose bladder cancer. CONSTITUTION: A kit for diagnosing bladder caner contains a methylate promoter of a bladder cancer marker gene, SIM2 (U80456) - single-minded homolog 2(Drosophila). A promoter or exon region contains at least one methylated CpG dinucleotide. A nucleic acid chip for diagnosing bladder cancer contains a probe which is hybridizable with a fragment having a promoter CpG island. A biomarker for diagnosing bladder cancer contains a methylated promoter of a SIM2(U80456)-single-minded homolog 2(Drosophila) gene.