AAV VECTORS EXPRESSING SEC1O FOR TREATING KIDNEY DAMAGE
摘要
<p>A method for enhancing repair of damaged mammalian tubular epithelial cells involves delivering to the tubular epithelial cells of a subject in need thereof a composition comprising an adeno-associated virus (AAV) comprising an AAV capsid having an amino acid sequence of a selected AAV serotype, and a minigene having AAV inverted terminal repeats and a Sec1O gene operatively linked to regulatory sequences that direct expression of Sec10 in the epithelial cells. In one embodiment, delivery is accomplished by retrograde intrauretal injection. In an embodiment the AAV vector includes a capsid of AAV serotype 2/8. Therapeutic compositions containing such AAV are provided.</p>
申请公布号
WO2011041502(A1)
申请公布日期
2011.04.07
申请号
WO2010US50852
申请日期
2010.09.30
申请人
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;LIPSCHUTZ, JOSHUA, H.;BENNETT, JEAN;CHUNG, DANIEL, C.
发明人
LIPSCHUTZ, JOSHUA, H.;BENNETT, JEAN;CHUNG, DANIEL, C.