AN ADAPTER MOLECULE FOR THE DELIVERY OF ADENOVIRUS VECTORS
摘要
<p>The invention relates to an adapter protein comprising a coxackievirus and adenovirus receptor (CAR) region and a human CD40 ligand and to the uses thereof for promoting adenoviral transduction of dendritic cells while at the same time promoting maturation of the DCs. The invention also relates to pharmaceutical compositions comprising said adapter protein and an adenovirus encoding an antigen and the uses thereof in a method for eliciting an immune response against the antigen encoded in said adenovirus as well as to antigen-loaded dendritic cells obtained the adaptor protein and an adenovirus and to the uses thereof in a method of eliciting an immune response against the antigen encoded in the adenovirus.</p>
申请公布号
EP2304034(A1)
申请公布日期
2011.04.06
申请号
EP20090749825
申请日期
2009.05.19
申请人
PROYECTO DE BIOMEDICINA CIMA, S.L.;THE UAB RESEARCH FOUNDATION
发明人
PEREBOEV, ALEXANDER;TSULADZE, GEORGE;BOGDASHIN, IGOR;ECHEVERRIA BEISTEGUI, ITZIAR;LASARTE SAGASTIBELZA, JUAN JOSE;PRIETO VALTUENA, JESUS MARIA;SAROBE UGARRIZA, PABLO