发明名称 |
PYRAZOLO-QUINAZOLINES AS PROTEIN KINASE ACTIVITY MODULATORS |
摘要 |
<p>The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C3-C7 cycloalkylamino residue at 8 position and an aryl, heterocyclyl or C3-C7 cycloalkyl as substituent of a carboxamide at 3 position of the molecule framework. The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.</p> |
申请公布号 |
EP2303891(A1) |
申请公布日期 |
2011.04.06 |
申请号 |
EP20090769164 |
申请日期 |
2009.06.17 |
申请人 |
NERVIANO MEDICAL SCIENCES S.R.L. |
发明人 |
CALDARELLI, MARINA;ANGIOLINI, MAURO;COLOMBO, RICCARDO;DISINGRINI, TERESA;NUVOLONI, STEFANO;POSTERI, HELENA;SALSA, MATTEO;SILVAGNI, MARCO |
分类号 |
A61K31/519;C07D239/70;C07D487/04 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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