发明名称 |
Inhibitors of aspartyl protease |
摘要 |
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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申请公布号 |
US7919523(B2) |
申请公布日期 |
2011.04.05 |
申请号 |
US20080217517 |
申请日期 |
2008.07.02 |
申请人 |
VERTEX PHARMACEUTICALS, INC. |
发明人 |
HALE MICHAEL R.;BAKER CHRISTOPHER T.;STAMMERS TIMOTHY A.;SHERRILL RONALD GEORGE;SPALTENSTEIN ANDREW;FURFINE ERIC STEVEN;MALTAIS FRANCOIS;ANDREWS, III CLARENCE WEBSTER;MILLER JOHN FRANKLIN;SAMANO VICENTE |
分类号 |
A61K31/357;C07C311/19;C07C311/29;C07C311/42;C07C311/46;C07C317/18;C07D307/20;C07D319/06;C07D493/04;C07F9/6561 |
主分类号 |
A61K31/357 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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