发明名称 |
Nucleic acids encoding humanized anti-tag 72 CC49 antbodies |
摘要 |
The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody includes a non-conservative amino acid substitution in a light chain complementarity determining region 3 of the CC49 antibody. In a further embodiment, the humanized CC49 antibody includes a non-conservative substitution of a first residue in a light chain complementarity determining region 3 and a substitution of a second residue in a complementarity determining region of the humanized CC49 antibody. In several of the embodiments, methods are disclosed for the use of a humanized CC49 antibody in the detection or treatment of a tumor in a subject. Also disclosed is a kit including the humanized CC49 antibody described herein. |
申请公布号 |
US7919607(B2) |
申请公布日期 |
2011.04.05 |
申请号 |
US20090474221 |
申请日期 |
2009.05.28 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KASHMIRI SYED V. S.;SCHLOM JEFFREY;PADLAN EDUARDO A. |
分类号 |
C07H21/04;A61K39/395;A61K51/10;C07K16/00;C07K16/30;C12N7/00;C12N15/00;C12P21/04;C12P21/08 |
主分类号 |
C07H21/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|