Use of IL-18 inhibitors

摘要

The invention relates to the use of an inhibitor of IL-18 in the preparation of a medicament for treatment and/or prevention of a cardiomyopathy, wherein the inhibitor of IL-18 is selected from an inhibitor of caspase-1 (ICE), of antibodies against IL-18, antibodies against any of the IL-18 receptor subunits, IL-18 binding proteins, isoforms, muteins, fused proteins or functional derivatives thereof inhibiting the biological activity of IL-18. Combinations of an IL-18 inhibitor and a TNF antagonist are also considered for the treatment and/or prevention of a cardiomyopathy.