发明名称 |
Methods of differentiating and protecting cells by modulating the P38/MEF2 pathway |
摘要 |
The present invention provides a method of differentiating progenitor cells to produce a population containing protected neuronal cells. A method of the invention includes the steps of contacting the progenitor cells with a differentiating agent; and introducing into the progenitor cells a nucleic acid molecule encoding a MEF2 polypeptide or an active fragment thereof, thereby differentiating the progenitor cells to produce a population containing protected neuronal cells. In one embodiment, the MEF2 polypeptide is human MEF2C or an active fragment thereof.
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申请公布号 |
US7919317(B2) |
申请公布日期 |
2011.04.05 |
申请号 |
US20010876187 |
申请日期 |
2001.06.05 |
申请人 |
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE |
发明人 |
LIPTON STUART A.;OKAMOTO SHU-ICHI |
分类号 |
C12N5/00;A61K35/12;C12N5/02;C12N5/071;C12N5/0793;C12N15/00;G01N33/68 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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