发明名称 Process for separating the diastereomers of RSS-snd SSS-N- a [1-carboxy -3-Phenylpropyl] lysylproline
摘要 A process for separating the diastereomers of RSS— and SSS—N-α[1-carboxy-3-phenylpropyl]lysylproline is described. Previous chromatographic processes for separating the diastereomers of this peptide active substance, such as for example adsorption chromatography, exhibited disadvantages with regard to the solvents used and throughput. These disadvantages do not occur if basic ion exchangers are used in the chromatographic separation of the diastereomers. In particular, purely aqueous solutions may be used as the eluent.
申请公布号 US2011077412(A1) 申请公布日期 2011.03.31
申请号 US20090589621 申请日期 2009.09.29
申请人 BOISIVON FREDERIC;DEBAS JEAN;RICHET GERARD 发明人 BOISIVON FREDERIC;DEBAS JEAN;RICHET GERARD
分类号 C07D207/16 主分类号 C07D207/16
代理机构 代理人
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