摘要 |
Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein. |
申请人 |
LIFE TECHNOLOGIES CORPORATION;HENDRICKS, STEPHEN P.;PHELAN, MICHAEL;PERIS, MARIAN;CHEN, CHENG-YAO;MAZUR, DANIEL;PENG, XINZHAN;CASTILLO, AMY |
发明人 |
HENDRICKS, STEPHEN P.;PHELAN, MICHAEL;PERIS, MARIAN;CHEN, CHENG-YAO;MAZUR, DANIEL;PENG, XINZHAN;CASTILLO, AMY |