A NOVEL METHOD FOR THE PRODUCTION OF A ANTIMICROBIAL PEPTIDE
摘要
<p>The present invention relates to a method of producing a peptide consisting of the amino acids 63 to 110 of dermcidin (SEQ ID NO: 3) comprising (a) culturing a host cell carrying a nucleic acid molecule encoding the peptide in an expressible form, and (b) optionally isolating the peptide from the culture. Furthermore, the invention relates to a nucleic acid molecule encoding a fusion protein comprising or consisting of (a) a peptide heterologous with regard to dermcidin protein-tag; and, C-terminally thereof (b) a peptide having the antimicrobial activity of dermcidin wherein the fusion protein contains an arginine residue located immediately N-terminally of the peptide of (b).</p>
申请公布号
WO2011036174(A1)
申请公布日期
2011.03.31
申请号
WO2010EP63971
申请日期
2010.09.22
申请人
B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATIONNETWORK AG;NAUMER, CHRISTIAN;KROHN, MICHAEL;TIFFERT, YVONNE;ECK, JUERGEN