摘要 |
The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a novel combination comprising the MEK inhibitor: N -{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d/]pyrimidin-1 (2H)-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and the PI3 kinase inhibitor: 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, andNN |
申请人 |
GLAXOSMITHKLINE LLC;AUGER, KURT, R.;BACHMAN, KURTIS, EARL;GILMER, TONA, M.;GREGOR, JAMES, G., JR.;GRESHOCK, JOEL, DAVID;LAQUERRE, SYLVIE;LIU, LI;MORRIS, SHANNON, RENAE |
发明人 |
AUGER, KURT, R.;BACHMAN, KURTIS, EARL;GILMER, TONA, M.;GREGOR, JAMES, G., JR.;GRESHOCK, JOEL, DAVID;LAQUERRE, SYLVIE;LIU, LI;MORRIS, SHANNON, RENAE |