| 摘要 |
Disclosed is a 3-pyridin-3-yl-1 ,5-diazatricyclo[5.2.2.0]undecane having a structure of the formula wherein: Y is either oxygen or sulfur, Z is either NR' or a covalent bond, A is either absent or a linker species selected from the group -CR' R"-, -CR' R"- CR'R"-, -CR'= CR'-, and -C2-, wherein R' and R" are defined in the specification, Ar is an aryl group, either carbocyclic or heterocyclic and Cy is a 5- or 6-membered heteroaromatic ring, wherein the junction between the azacycle and the azabicycle can be characterized by any of the various relative and absolute stereochemical configurations at the junction sites (e.g., cis or trans, R or S) and pharmaceutically acceptable salts thereof. Also disclosed is a composition comprising said undecane and the use in the treatment of pain, dementia, mania and depression.
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