摘要 |
<p>Disclosed is a method for screening for a medicinal agent that can decrease a body weight, a medicinal agent that can reduce a visceral fat, a medicinal agent that can reduce a triglyceride in the liver, and a medicinal agent that can ameliorate obesity and fatty liver. The method involves a step of measuring the inhibitory activity of a candidate substance on a sphingomyelin synthase, wherein the candidate substance is determined to have at least one function selected from the group consisting of an anti-obesity agent, a visceral fat-reducing agent, a fatty liver-treating agent and an adiponectin expression enhancer when the candidate substance has an inhibitory activity on the sphingomyelin synthase.</p> |
申请人 |
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY;SHIONOGI & CO., LTD.;MITSUTAKE, SUSUMU;IGARASHI, YASUYUKI;ZAMA, KOTA;YOSHIDA, TETSUYA;TANAKA, YOSHIKAZU;TAKEMOTO, HIROSHI |
发明人 |
MITSUTAKE, SUSUMU;IGARASHI, YASUYUKI;ZAMA, KOTA;YOSHIDA, TETSUYA;TANAKA, YOSHIKAZU;TAKEMOTO, HIROSHI |