| 发明名称 |
CARDIOVASCULAR SAFETY ASSAY |
| 摘要 |
The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity of compounds during the development of new therapeutics and other agents.
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| 申请公布号 |
US2011076696(A1) |
申请公布日期 |
2011.03.31 |
| 申请号 |
US20100860387 |
申请日期 |
2010.08.20 |
| 申请人 |
JANSSEN PHARMACEUTICA, N.V. |
发明人 |
HEYLEN GODELIEVE IRMA CHRISTINE MARIA;JANSSEN CORNELUS GERARDUS MARIA;MIREK JURZAK;VAN ASSOUW HENRICUS PETRUS MARTINUS MARIA |
| 分类号 |
G01N33/567;C07D401/12;C07K14/47;C12N5/10;C12N15/09;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/566;G01N33/60;G01N33/68 |
主分类号 |
G01N33/567 |
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