BETA-DEFENSIN 2 GENETIC VARIATION PREDICTS H. PYLORI SUSCEPTIBILITY

摘要

The present invention relates to correlating high gene copy number and/or the overexpression of ß-defensin 2 ("BD2") with susceptibility to disease conditions resulting from, associated with or mediated by Helicobacter pylori infection, for example, susceptibility to peptic ulcer, non-ulcer dyspepsia, gastric cancer (e.g., gastric adenocarcinoma), and mucosa associated lymphoid tissue (MALT) lymphoma.