Controlled release pharmaceutical composition comprising an acid-insoluble polymer and bioadhesive polymer

摘要

Disclosed is a rapidly disintegrating oral controlled release pharmaceutical composition comprising at least one active ingredient is amoxicillin, and a polymer system comprising of at least two polymers wherein one polymer is methacrylic acid polymer as an acid insoluble polymer and another polymer is polycarbophil as a bioadhesive polymer, which retard the release of the active ingredient in the stomach while providing rapid release of the said active ingredient in the pH above 5.5, optionally with other pharmaceutically acceptable excipients. The process for preparing the above composition is also disclosed.