发明名称 |
Means and Methods for Influencing Electrical Activity of Cells |
摘要 |
The invention provides means and methods for providing a cell with a spontaneous electrical activity and means and methods for increasing the depolarization rate of a cell having a spontaneous electrical activity. Means and methods are provided comprising: providing a cell with a compound capable of providing and/or increasing a pacemaker current If, and diminishing electrical coupling between said cell and surrounding cells and/or reducing the inward rectifier current IK1 of said cell, and or increasing the availability of INa at depolarized potentials, preferably using overexpression of additional sodium channels.
|
申请公布号 |
US2011077702(A1) |
申请公布日期 |
2011.03.31 |
申请号 |
US20100891172 |
申请日期 |
2010.09.27 |
申请人 |
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM |
发明人 |
BOINK GERARD J.J.;TAN HANNO L.;MILO THOMAS JACQUES DE BAKKER |
分类号 |
A61N1/362;A61K31/7088;A61K35/12;A61N1/00;C12N5/02;C12N15/63 |
主分类号 |
A61N1/362 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|